※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (1)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Art-0695	AT4G14480	O23304	BLUS1
2		iEKPD-Art-0091	AT1G23700	A0A1P8AML6	At1g23700
3		iEKPD-Art-0242	AT1G70430	A0A1P8AWS0	At1g70430
4		iEKPD-Art-0285	AT1G79640	F4IF81	At1g79640
5		iEKPD-Art-0679	AT4G10730	F4JMF4	At4g10730
6		iEKPD-Art-0743	AT4G24100	A0A1P8B4A5	At4g24100
7		iEKPD-Art-0863	AT5G14720	Q84WU5	At5g14720
8		iEKPD-Art-0157	AT1G53165	F4HPR9	ATMAP4K ALPHA1
9		iEKPD-Art-0491	AT3G15220	Q9LDN6	map4kalpha2
10		iEKPD-Art-0233	AT1G69220	O24527	SIK1