※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ast-0024	CADATEAG00001567	Q0CY84	ATEG_01350
2		iEKPD-Ast-0132	CADATEAG00009482	Q0CQ95	ATEG_04139
3		iEKPD-Ast-0137	CADATEAG00009589	Q0CPS0	ATEG_04314
4		iEKPD-Ast-0017	CADATEAG00001055	Q0CJU9	ATEG_06035
5		iEKPD-Ast-0036	CADATEAG00002417	Q0CAV5	ATEG_09179
6		iEKPD-Ast-0148	CADATEAG00010122	Q0CA40	ATEG_09444