※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Blg-0004	BGHDH14_bgh00182	N1JI04	BGHDH14_bgh00182
2		iEKPD-Blg-0024	BGHDH14_bgh01479	N1JB71	BGHDH14_bgh01479
3		iEKPD-Blg-0050	BGHDH14_bgh03642	N1J784	BGHDH14_bgh03642
4		iEKPD-Blg-0056	BGHDH14_bgh04362	N1JJJ8	BGHDH14_bgh04362
5		iEKPD-Blg-0085	BGHDH14_bgh06216	N1JCZ9	BGHDH14_bgh06216
6		iEKPD-Blg-0102	BGHDH14_bghG001465000001001	N1J703	BGHDH14_bghG001465000001001