※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Chr-0019	CHLREDRAFT_103515	A8J0P4	CHLREDRAFT_103515
2		iEKPD-Chr-0099	CHLREDRAFT_120498	A8J8U8	CHLREDRAFT_120498
3		iEKPD-Chr-0106	CHLREDRAFT_121971	A8JD67	CHLREDRAFT_121971
4		iEKPD-Chr-0196	CHLREDRAFT_146743	A8HML9	CHLREDRAFT_146743
5		iEKPD-Chr-0216	CHLREDRAFT_149078	A8J3B9	CHLREDRAFT_149078
6		iEKPD-Chr-0240	CHLREDRAFT_151969	A8JA73	CHLREDRAFT_151969
7		iEKPD-Chr-0297	CHLREDRAFT_168621	A8HT76	CHLREDRAFT_168621
8		iEKPD-Chr-0330	CHLREDRAFT_172777	A8IX96	CHLREDRAFT_172777
9		iEKPD-Chr-0381	CHLREDRAFT_179145	A8JEN4	CHLREDRAFT_179145
10		iEKPD-Chr-0434	CHLREDRAFT_187846	A8HRC0	CHLREDRAFT_187846
11		iEKPD-Chr-0437	CHLREDRAFT_188280	A8IFI7	CHLREDRAFT_188280
12		iEKPD-Chr-0474	CHLREDRAFT_192785	A8J8E9	CHLREDRAFT_192785
13		iEKPD-Chr-0517	CHLREDRAFT_205721	A8IK77	CHLREDRAFT_205721
14		iEKPD-Chr-0119	CHLREDRAFT_127161	A8I6J1	MAPKKKK1