※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Glm-0929	GLYMA_08G334300
2		iEKPD-Glm-1729	GLYMA_15G048500
3		iEKPD-Glm-2179	GLYMA_19G007300	K7MVS5	100778837
4		iEKPD-Glm-0879	GLYMA_08G223700	K7L854	100780339
5		iEKPD-Glm-2353	GLYMA_20G217200	I1NIH1	100783699
6		iEKPD-Glm-0426	GLYMA_05G006700	I1K1G9	100784402
7		iEKPD-Glm-0026	GLYMA_01G061500	K7K255	100784666
8		iEKPD-Glm-2377	GLYMA_U025600	K7LV78	100786501
9		iEKPD-Glm-2266	GLYMA_20G067600	K7N1Y6	100793223
10		iEKPD-Glm-0129	GLYMA_02G119700	I1JEG8	100804995
11		iEKPD-Glm-1419	GLYMA_13G001900	K7LY86	100809903
12		iEKPD-Glm-1131	GLYMA_10G173000	I1LBY1	100811264
13		iEKPD-Glm-1544	GLYMA_13G274500	K7M2A2	100814188
14		iEKPD-Glm-1410	GLYMA_12G226300	I1LV29	100815042
15		iEKPD-Glm-0659	GLYMA_07G002900	K7KYT5	100819537
16		iEKPD-Glm-0017	GLYMA_01G033600	K7K1J5	GLYMA_01G033600
17		iEKPD-Glm-0602	GLYMA_06G238000	K7KWZ4	GLYMA_06G238000
18		iEKPD-Glm-1345	GLYMA_12G132600	K7LUJ0	GLYMA_12G132600
19		iEKPD-Glm-1582	GLYMA_13G349800	I1M5C0	GLYMA_13G349800