※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Lua-0009	TanjilG_01362	A0A1J7INZ9	TanjilG_01362
2		iEKPD-Lua-0029	TanjilG_03668	A0A1J7GXF6	TanjilG_03668
3		iEKPD-Lua-0065	TanjilG_06336	A0A1J7HXP7	TanjilG_06336
4		iEKPD-Lua-0279	TanjilG_14741	A0A1J7FQW1	TanjilG_14741
5		iEKPD-Lua-0288	TanjilG_15074	A0A1J7GKR4	TanjilG_15074
6		iEKPD-Lua-0395	TanjilG_20865	A0A1J7INT6	TanjilG_20865
7		iEKPD-Lua-0490	TanjilG_25172	A0A1J7GWC2	TanjilG_25172