※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-0101	MANES_02G003400	A0A2C9WBX3	MANES_02G003400
2		iEKPD-Mae-0252	MANES_03G106600	A0A2C9W8W2	MANES_03G106600
3		iEKPD-Mae-0286	MANES_03G167700	A0A2C9W869	MANES_03G167700
4		iEKPD-Mae-0343	MANES_04G098600	A0A2C9W2I6	MANES_04G098600
5		iEKPD-Mae-0432	MANES_05G112600	A0A2C9VWQ1	MANES_05G112600
6		iEKPD-Mae-0945	MANES_11G070900	A0A2C9UZ54	MANES_11G070900
7		iEKPD-Mae-1080	MANES_13G029700	A0A2C9UNL2	MANES_13G029700
8		iEKPD-Mae-1230	MANES_15G089100	A0A251J4F2	MANES_15G089100
9		iEKPD-Mae-1257	MANES_15G165300	A0A2C9UGK7	MANES_15G165300
10		iEKPD-Mae-1411	MANES_17G116100	A0A2C9U771	MANES_17G116100