※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mel-0036	MELLADRAFT_124623	F4S110	Cla4
2		iEKPD-Mel-0031	MELLADRAFT_117822	F4S1W0	MELLADRAFT_117822
3		iEKPD-Mel-0037	MELLADRAFT_124624	F4RH37	MELLADRAFT_124624
4		iEKPD-Mel-0049	MELLADRAFT_29877	F4RFM2	MELLADRAFT_29877
5		iEKPD-Mel-0051	MELLADRAFT_31685	F4RFM3	MELLADRAFT_31685
6		iEKPD-Mel-0092	MELLADRAFT_47293	F4RC59	MELLADRAFT_47293
7		iEKPD-Mel-0106	MELLADRAFT_50865	F4S958	MELLADRAFT_50865