※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Miv-0025	MVLG_01447	U5H257	MVLG_01447
2		iEKPD-Miv-0067	MVLG_03473	U5H8A8	MVLG_03473
3		iEKPD-Miv-0078	MVLG_04000	U5H9W3	MVLG_04000
4		iEKPD-Miv-0081	MVLG_04055	U5HA19	MVLG_04055
5		iEKPD-Miv-0091	MVLG_04513	U5HBG2	MVLG_04513
6		iEKPD-Miv-0097	MVLG_04870	U5HCI9	MVLG_04870
7		iEKPD-Miv-0133	MVLG_07087	U5HJ99	MVLG_07087