※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (0)  or Unreviewed (28) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mim-0017	ENSMICG00000000982.3
2		iEKPD-Mim-0020	ENSMICG00000001208.3
3		iEKPD-Mim-0071	ENSMICG00000003905.3
4		iEKPD-Mim-0082	ENSMICG00000004379.3
5		iEKPD-Mim-0083	ENSMICG00000004384.3
6		iEKPD-Mim-0089	ENSMICG00000004517.3
7		iEKPD-Mim-0108	ENSMICG00000005354.3
8		iEKPD-Mim-0116	ENSMICG00000005918.3
9		iEKPD-Mim-0120	ENSMICG00000006193.3
10		iEKPD-Mim-0128	ENSMICG00000006625.3
11		iEKPD-Mim-0148	ENSMICG00000007683.3
12		iEKPD-Mim-0180	ENSMICG00000009064.3
13		iEKPD-Mim-0181	ENSMICG00000009090.3
14		iEKPD-Mim-0235	ENSMICG00000012111.3
15		iEKPD-Mim-0243	ENSMICG00000012416.3
16		iEKPD-Mim-0247	ENSMICG00000012473.3
17		iEKPD-Mim-0249	ENSMICG00000012784.3
18		iEKPD-Mim-0257	ENSMICG00000013218.3
19		iEKPD-Mim-0260	ENSMICG00000013292.3
20		iEKPD-Mim-0276	ENSMICG00000013952.3
21		iEKPD-Mim-0283	ENSMICG00000014358.3
22		iEKPD-Mim-0289	ENSMICG00000014926.3
23		iEKPD-Mim-0292	ENSMICG00000015101.3
24		iEKPD-Mim-0295	ENSMICG00000015365.3
25		iEKPD-Mim-0329	ENSMICG00000016445.3
26		iEKPD-Mim-0332	ENSMICG00000016556.3
27		iEKPD-Mim-0350	ENSMICG00000026424.2
28		iEKPD-Mim-0398	ENSMICG00000034038.2