※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Nia-0115	A4A49_06671	A0A1J6IJL1	BLUS1_0
2		iEKPD-Nia-0148	A4A49_08987	A0A1J6IYQ3	BLUS1_1
3		iEKPD-Nia-0466	A4A49_32737	A0A1J6KGS9	BLUS1_3
4		iEKPD-Nia-0621	A4A49_42154	A0A1J6K8I7	BLUS1_5
5		iEKPD-Nia-0335	A4A49_24475	A0A1J6KAY8	BLUS1_6
6		iEKPD-Nia-0458	A4A49_32044	A0A1J6II66	BLUS1_7
7		iEKPD-Nia-0637	A4A49_53196	A0A1J6IA95	BLUS1_8
8		iEKPD-Nia-0240	A4A49_18333	A0A1J6INE6	YDA_7