※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Php-0263	PP1S201_21V6
2		iEKPD-Php-0633	PP1S4_81V6
3		iEKPD-Php-0672	PP1S59_173V6
4		iEKPD-Php-0716	PP1S68_168V6
5		iEKPD-Php-0108	PP1S13_360V6	A9RK00	PHYPADRAFT_115540
6		iEKPD-Php-0401	PP1S27_49V6	A9RT39	PHYPADRAFT_119152
7		iEKPD-Php-0561	PP1S39_232V6	A9S0F3	PHYPADRAFT_122214
8		iEKPD-Php-0328	PP1S227_24V6	A9TGS0	PHYPADRAFT_145446
9		iEKPD-Php-0571	PP1S407_24V6	A9U0V0	PHYPADRAFT_153982
10		iEKPD-Php-0002	PP1S100_147V6	A9SP74	PHYPADRAFT_165977
11		iEKPD-Php-0265	PP1S202_35V6	A9TC54	PHYPADRAFT_169267
12		iEKPD-Php-0797	PP1S98_82V6	A9SNT3	PHYPADRAFT_186825
13		iEKPD-Php-0090	PP1S134_154V6	A9SXV7	PHYPADRAFT_189546
14		iEKPD-Php-0663	PP1S56_2V6	A9S8D4	PHYPADRAFT_33547
15		iEKPD-Php-0764	PP1S84_190V6	A9SJB6	PHYPADRAFT_80194
16		iEKPD-Php-0465	PP1S31_249V6	A9RVK0	PHYPA_015355