※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-0884	SELMODRAFT_449475	D8S3L0	MAP4K4
2		iEKPD-Sem-0066	SELMODRAFT_108899	D8S5K8	SELMODRAFT_108899
3		iEKPD-Sem-0139	SELMODRAFT_117572	D8SIJ3	SELMODRAFT_117572
4		iEKPD-Sem-0150	SELMODRAFT_119926	D8SLM1	SELMODRAFT_119926
5		iEKPD-Sem-0165	SELMODRAFT_122243	D8SQ18	SELMODRAFT_122243
6		iEKPD-Sem-0175	SELMODRAFT_124544	D8STR1	SELMODRAFT_124544
7		iEKPD-Sem-0270	SELMODRAFT_136846	D8TCI8	SELMODRAFT_136846
8		iEKPD-Sem-0579	SELMODRAFT_30736	D8RMI8	SELMODRAFT_30736
9		iEKPD-Sem-0660	SELMODRAFT_406890	D8R397	SELMODRAFT_406890
10		iEKPD-Sem-0703	SELMODRAFT_413912	D8RR11	SELMODRAFT_413912
11		iEKPD-Sem-0761	SELMODRAFT_42395	D8R055	SELMODRAFT_42395
12		iEKPD-Sem-0827	SELMODRAFT_43202	D8SUE7	SELMODRAFT_43202
13		iEKPD-Sem-0835	SELMODRAFT_437225	D8QPF2	SELMODRAFT_437225
14		iEKPD-Sem-0852	SELMODRAFT_442893	D8RWY5	SELMODRAFT_442893
15		iEKPD-Sem-0867	SELMODRAFT_445760	D8SL25	SELMODRAFT_445760
16		iEKPD-Sem-1075	SELMODRAFT_83791	D8R2D0	SELMODRAFT_83791
17		iEKPD-Sem-1128	SELMODRAFT_92988	D8RFM9	SELMODRAFT_92988
18		iEKPD-Sem-1131	SELMODRAFT_93150	D8RH00	SELMODRAFT_93150
19		iEKPD-Sem-1158	SELMODRAFT_99238	D8RQE9	SELMODRAFT_99238