※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (0)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-1291	Si036560m.g	K4ACF3	LOC101753665
2		iEKPD-Sei-1192	Si034400m.g	K4A696	LOC101756069
3		iEKPD-Sei-0643	Si019743m.g	K3YZN3	LOC101763952
4		iEKPD-Sei-0234	Si005975m.g	K3XVL7	LOC101767987
5		iEKPD-Sei-0551	Si016522m.g	K3YQH9	LOC101770595
6		iEKPD-Sei-0729	Si021658m.g	K3Z540	LOC101772118
7		iEKPD-Sei-1176	Si034257m.g	K4A5V3	LOC101775953
8		iEKPD-Sei-1179	Si034278m.g	K4A5X4	LOC101784831
9		iEKPD-Sei-1014	Si029115m.g	A0A0Q3TSR7	SETIT_0291151mg