※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sob-0036	SORBI_3001G085700	Q8LKU7	170F8.3
2		iEKPD-Sob-0040	SORBI_3001G094000	A0A1B6QI40	SORBI_3001G094000
3		iEKPD-Sob-0071	SORBI_3001G193000	A0A1B6QJT2	SORBI_3001G193000
4		iEKPD-Sob-0162	SORBI_3001G450500	C5WSL9	SORBI_3001G450500
5		iEKPD-Sob-0185	SORBI_3001G533700	A0A1B6QR04	SORBI_3001G533700
6		iEKPD-Sob-0308	SORBI_3002G313100	C5X9D0	SORBI_3002G313100
7		iEKPD-Sob-0593	SORBI_3004G064200	A0A194YP53	SORBI_3004G064200
8		iEKPD-Sob-0680	SORBI_3004G327000	C5XUC7	SORBI_3004G327000
9		iEKPD-Sob-0719	SORBI_3005G055900	A0A1B6PQC8	SORBI_3005G055900
10		iEKPD-Sob-0983	SORBI_3008G011200	A0A1B6PAN6	SORBI_3008G011200
11		iEKPD-Sob-1220	SORBI_3010G139600	A0A1W0VSW7	SORBI_3010G139600