※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (1)  or Unreviewed (29) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0192	ENSSSCG00000011253.3	Q863I2	OXSR1
2		iEKPD-Sus-0043	ENSSSCG00000002962.3	A0A287AZW8	MAP4K1
3		iEKPD-Sus-0227	ENSSSCG00000013020.3	F1RQR1	MAP4K2
4		iEKPD-Sus-0127	ENSSSCG00000008475.4	F1S4T3	MAP4K3
5		iEKPD-Sus-0121	ENSSSCG00000008164.3	F1STG5	MAP4K4
6		iEKPD-Sus-0439	ENSSSCG00000036634.1	A0A287BMI6	MAP4K5
7		iEKPD-Sus-0312	ENSSSCG00000017917.3	F1RFV9	MINK1
8		iEKPD-Sus-0185	ENSSSCG00000011059.3	F1RTW9	MYO3A
9		iEKPD-Sus-0411	ENSSSCG00000032177.1	A0A287AZI8	MYO3B
10		iEKPD-Sus-0217	ENSSSCG00000012546.3	F1RXN7	NRK
11		iEKPD-Sus-0251	ENSSSCG00000014878.4	F1SUK2	PAK1
12		iEKPD-Sus-0205	ENSSSCG00000011843.3	F1SQW0	PAK2
13		iEKPD-Sus-0349	ENSSSCG00000025306.2	A0A287BNI8	PAK3
14		iEKPD-Sus-0320	ENSSSCG00000021333.2	I3LSG7	PAK4
15		iEKPD-Sus-0106	ENSSSCG00000007061.3	F1SBK7	PAK5
16		iEKPD-Sus-0074	ENSSSCG00000004781.3	F1SS32	PAK6
17		iEKPD-Sus-0174	ENSSSCG00000010606.3	A0A287APG0	SLK
18		iEKPD-Sus-0331	ENSSSCG00000022478.2	I3LBD5	STK10
19		iEKPD-Sus-0148	ENSSSCG00000009511.3	A0A287B0C4	STK24
20		iEKPD-Sus-0279	ENSSSCG00000016372.3	F1SIN8	STK25
21		iEKPD-Sus-0319	ENSSSCG00000021205.2	B7U6F4	STK26
22		iEKPD-Sus-0091	ENSSSCG00000006074.3	M3UZA8	STK3
23		iEKPD-Sus-0332	ENSSSCG00000022496.2	I3LIX4	STK39
24		iEKPD-Sus-0397	ENSSSCG00000030820.2	K7GR63	STK4
25		iEKPD-Sus-0299	ENSSSCG00000017290.3	A0A287A131	STRADA
26		iEKPD-Sus-0401	ENSSSCG00000031271.1	A0A287AC44	STRADB
27		iEKPD-Sus-0310	ENSSSCG00000017790.3	F1RN84	TAOK1
28		iEKPD-Sus-0408	ENSSSCG00000031967.1	I3LK42	TAOK2
29		iEKPD-Sus-0158	ENSSSCG00000009850.3	F1RKG9	TAOK3
30		iEKPD-Sus-0379	ENSSSCG00000028905.2	A0A287BA39	TNIK