※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0001	ENSTGUG00000000005.1	H0YP07
2		iEKPD-Tag-0003	ENSTGUG00000000075.1	H0YP82
3		iEKPD-Tag-0012	ENSTGUG00000000383.1	H0YQ46
4		iEKPD-Tag-0013	ENSTGUG00000000393.1
5		iEKPD-Tag-0040	ENSTGUG00000001058.1	H0YS29
6		iEKPD-Tag-0053	ENSTGUG00000001397.1	H0YT31
7		iEKPD-Tag-0103	ENSTGUG00000003029.1	H0YXW2
8		iEKPD-Tag-0104	ENSTGUG00000003047.1	H0YXX3
9		iEKPD-Tag-0120	ENSTGUG00000003518.1	H0YZA0
10		iEKPD-Tag-0125	ENSTGUG00000003740.1	H0YZX3
11		iEKPD-Tag-0204	ENSTGUG00000006253.1	H0Z778
12		iEKPD-Tag-0211	ENSTGUG00000006415.1	H0Z7P2
13		iEKPD-Tag-0396	ENSTGUG00000013675.1	H0ZTY0
14		iEKPD-Tag-0398	ENSTGUG00000013686.1	H0ZU01
15		iEKPD-Tag-0400	ENSTGUG00000013704.1	H0ZU13
16		iEKPD-Tag-0401	ENSTGUG00000013724.1	H0ZU36
17		iEKPD-Tag-0407	ENSTGUG00000013856.1	H0ZUG5
18		iEKPD-Tag-0408	ENSTGUG00000013861.1	H0ZUG6
19		iEKPD-Tag-0409	ENSTGUG00000013873.1	H0ZUK2
20		iEKPD-Tag-0411	ENSTGUG00000013955.1	H0ZUR4
21		iEKPD-Tag-0420	ENSTGUG00000014354.1	H0ZVT0
22		iEKPD-Tag-0423	ENSTGUG00000014365.1	H0ZVW1
23		iEKPD-Tag-0428	ENSTGUG00000014586.1	H0ZWG1
24		iEKPD-Tag-0431	ENSTGUG00000014596.1	H0ZWG7
25		iEKPD-Tag-0433	ENSTGUG00000014645.1	H0ZWL7
26		iEKPD-Tag-0435	ENSTGUG00000014676.1	H0ZWP9
27		iEKPD-Tag-0437	ENSTGUG00000014689.1	H0ZWR2
28		iEKPD-Tag-0441	ENSTGUG00000014731.1	H0ZWU9
29		iEKPD-Tag-0442	ENSTGUG00000014739.1	H0ZWV4
30		iEKPD-Tag-0443	ENSTGUG00000014769.1	H0ZWY1
31		iEKPD-Tag-0444	ENSTGUG00000014799.1	H0ZX02
32		iEKPD-Tag-0448	ENSTGUG00000014907.1	H0ZXB8
33		iEKPD-Tag-0449	ENSTGUG00000014932.1	H0ZXD0
34		iEKPD-Tag-0453	ENSTGUG00000015000.1	H0ZXK4
35		iEKPD-Tag-0454	ENSTGUG00000015007.1	H0ZXL3
36		iEKPD-Tag-0462	ENSTGUG00000015233.1	H0ZY70
37		iEKPD-Tag-0466	ENSTGUG00000015265.1	H0ZYA5
38		iEKPD-Tag-0472	ENSTGUG00000015498.1	H0ZYY2
39		iEKPD-Tag-0474	ENSTGUG00000015515.1	H0ZZ04
40		iEKPD-Tag-0476	ENSTGUG00000015568.1	H0ZZ59
41		iEKPD-Tag-0478	ENSTGUG00000015592.1	H0ZZ75
42		iEKPD-Tag-0481	ENSTGUG00000015817.1	H0ZZT5
43		iEKPD-Tag-0483	ENSTGUG00000015843.1	H0ZZW7
44		iEKPD-Tag-0485	ENSTGUG00000015957.1	H1A066
45		iEKPD-Tag-0489	ENSTGUG00000016026.1	H1A0E0
46		iEKPD-Tag-0490	ENSTGUG00000016082.1	H1A0K0
47		iEKPD-Tag-0491	ENSTGUG00000016145.1	H1A0Q5
48		iEKPD-Tag-0495	ENSTGUG00000016226.1	H1A0Y2
49		iEKPD-Tag-0496	ENSTGUG00000016297.1	H1A159
50		iEKPD-Tag-0497	ENSTGUG00000016322.1	H1A182
51		iEKPD-Tag-0499	ENSTGUG00000016398.1	H1A1F3
52		iEKPD-Tag-0500	ENSTGUG00000016405.1	H1A1H2
53		iEKPD-Tag-0504	ENSTGUG00000016448.1	H1A1I3
54		iEKPD-Tag-0510	ENSTGUG00000016493.1	H1A1N3
55		iEKPD-Tag-0515	ENSTGUG00000016636.1	H1A226
56		iEKPD-Tag-0517	ENSTGUG00000016738.1	H1A2D0
57		iEKPD-Tag-0518	ENSTGUG00000016741.1	H1A2D6
58		iEKPD-Tag-0520	ENSTGUG00000016760.1	H1A2F1
59		iEKPD-Tag-0521	ENSTGUG00000016774.1	H1A2G5
60		iEKPD-Tag-0523	ENSTGUG00000016946.1	H1A2X6
61		iEKPD-Tag-0528	ENSTGUG00000017061.1	H1A387
62		iEKPD-Tag-0541	ENSTGUG00000017214.1	H1A3N1
63		iEKPD-Tag-0552	ENSTGUG00000017512.1	H1A4H7
64		iEKPD-Tag-0553	ENSTGUG00000017514.1	H1A4I0
65		iEKPD-Tag-0554	ENSTGUG00000017521.1	H1A4I5
66		iEKPD-Tag-0555	ENSTGUG00000017522.1	H1A4I6
67		iEKPD-Tag-0556	ENSTGUG00000017535.1	H1A4K0
68		iEKPD-Tag-0557	ENSTGUG00000017537.1	H1A4K2
69		iEKPD-Tag-0422	ENSTGUG00000014357.1	H0ZVU4	LOC100223901
70		iEKPD-Tag-0470	ENSTGUG00000015383.1	H0ZYM4	LOC100230733
71		iEKPD-Tag-0416	ENSTGUG00000014283.1	H0ZVM4	LOC105760143
72		iEKPD-Tag-0077	ENSTGUG00000002002.1	H0YUX7	MAP4K3
73		iEKPD-Tag-0299	ENSTGUG00000009900.1	H0ZI32	MAP4K4
74		iEKPD-Tag-0388	ENSTGUG00000013168.1	H0ZSH0	MAP4K5
75		iEKPD-Tag-0048	ENSTGUG00000001156.1	H0YSD2	MYO3A
76		iEKPD-Tag-0254	ENSTGUG00000008038.1	H0ZCI4	MYO3B
77		iEKPD-Tag-0111	ENSTGUG00000003240.1	H0YYH4	NRK
78		iEKPD-Tag-0017	ENSTGUG00000000423.1	H0YQ83	OXSR1
79		iEKPD-Tag-0384	ENSTGUG00000013034.1	H0ZS31	PAK1
80		iEKPD-Tag-0186	ENSTGUG00000005832.1	H0Z619	PAK2
81		iEKPD-Tag-0149	ENSTGUG00000004384.1	H0Z1X4	PAK3
82		iEKPD-Tag-0200	ENSTGUG00000006182.1	H0Z721	PAK5
83		iEKPD-Tag-0233	ENSTGUG00000007255.1	H0ZA82	PAK6
84		iEKPD-Tag-0307	ENSTGUG00000010378.1	H0ZJF9	SLK
85		iEKPD-Tag-0009	ENSTGUG00000000289.1	H0YPU8	STK10
86		iEKPD-Tag-0328	ENSTGUG00000011049.1	H0ZLC5	STK24
87		iEKPD-Tag-0196	ENSTGUG00000006107.1	H0Z6U3	STK25
88		iEKPD-Tag-0355	ENSTGUG00000012023.1	H0ZP55	STK3
89		iEKPD-Tag-0241	ENSTGUG00000007554.1	H0ZB41	STK39
90		iEKPD-Tag-0167	ENSTGUG00000005057.1	H0Z3U9	STK4
91		iEKPD-Tag-0075	ENSTGUG00000001939.1	H0YUN3	STRADA
92		iEKPD-Tag-0306	ENSTGUG00000010255.1	H0ZJ19	STRADB
93		iEKPD-Tag-0208	ENSTGUG00000006304.1	H0Z7F5	TAOK1
94		iEKPD-Tag-0286	ENSTGUG00000009171.1	H0ZFW2	TAOK3