Danio rerio      TK/FGFR


※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular kinase domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515


There are 5 genes.  Reviewed (4 or Unreviewed (1

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Dar-0073
ENSDARG00000011027.11
Q90Z00
fgfr1a
2
iEKPD-Dar-0380
ENSDARG00000058115.8
Q8JG38
fgfr2
3
iEKPD-Dar-0027
ENSDARG00000004782.12
Q9I8X3
fgfr3
4
iEKPD-Dar-0464
ENSDARG00000069105.5
Q90413
fgfr4
5
iEKPD-Dar-0076
ENSDARG00000011190.10
G1K2P2
fgfr1b