Homo sapiens      TK/FGFR


※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular kinase domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515


There are 4 genes.  Reviewed (4 or Unreviewed (0

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Hos-0071
ENSG00000077782.19
P11362
FGFR1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR
2
iEKPD-Hos-0045
ENSG00000066468.22
P21802
FGFR2; BEK; KGFR; KSAM
3
iEKPD-Hos-0049
ENSG00000068078.17
P22607
FGFR3; JTK4
4
iEKPD-Hos-0315
ENSG00000160867.14
P22455
FGFR4; JTK2; TKF