※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular kinase domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515

  Reviewed (0)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ict-0034	ENSSTOG00000001175.3	A0A287D0Q7	FGFR1
2		iEKPD-Ict-0094	ENSSTOG00000003979.3	I3M3D7	FGFR2
3		iEKPD-Ict-0025	ENSSTOG00000000815.3	A0A287DGH2	FGFR3
4		iEKPD-Ict-0012	ENSSTOG00000000431.3	I3LWL9	FGFR4