※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular kinase domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515

  Reviewed (0)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mam-0401	ENSMMUG00000022478.3	A0A1D5R2V9	FGFR1
2		iEKPD-Mam-0157	ENSMMUG00000009594.3	A0A1D5QYN7	FGFR2
3		iEKPD-Mam-0350	ENSMMUG00000019945.3	F7FZS3	FGFR3
4		iEKPD-Mam-0070	ENSMMUG00000004919.3	F7CEB6	FGFR4