※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular kinase domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515

  Reviewed (4)  or Unreviewed (0) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mum-0279	ENSMUSG00000031565.18	P16092	Fgfr1; Flg
2		iEKPD-Mum-0263	ENSMUSG00000030849.18	P21803	Fgfr2; Bek; Ect1
3		iEKPD-Mum-0407	ENSMUSG00000054252.17	Q61851	Fgfr3; Mfr3; Sam3
4		iEKPD-Mum-0036	ENSMUSG00000005320.9	Q03142	Fgfr4; Fgfr-4; Mpk-11