※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular kinase domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Orn-0293	ENSONIG00000010192.1	I3JVC0	fgfr2
2		iEKPD-Orn-0506	ENSONIG00000017319.1	I3KL47	fgfr4
3		iEKPD-Orn-0380	ENSONIG00000012350.1	I3K361	LOC100689850
4		iEKPD-Orn-0328	ENSONIG00000011012.1	I3JYB1	LOC100698136
5		iEKPD-Orn-0388	ENSONIG00000012609.1	I3K424	LOC100707841