※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular kinase domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ora-0161	ENSOANG00000007493.2	F6QKY2
2		iEKPD-Ora-0431	ENSOANG00000028708.1	K7EGI4
3		iEKPD-Ora-0072	ENSOANG00000003252.3	F6SM70	FGFR1
4		iEKPD-Ora-0009	ENSOANG00000000474.3	F7EXS2	FGFR2
5		iEKPD-Ora-0075	ENSOANG00000003354.3	F6VBA5	FGFR3
6		iEKPD-Ora-0444	ENSOANG00000029096.1	K7EG82	LOC100084628