Papio anubis      TK/FGFR


※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular kinase domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515


There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Paa-0169
ENSPANG00000012485.2
A0A096MT31
FGFR1
2
iEKPD-Paa-0309
ENSPANG00000020505.2
A0A2I3LIL7
FGFR2
3
iEKPD-Paa-0416
ENSPANG00000024533.2
A0A2I3LS46
FGFR3
4
iEKPD-Paa-0165
ENSPANG00000012360.3
A0A096N6L3
FGFR4