※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular kinase domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515

  Reviewed (0)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sah-0408	ENSSHAG00000017666.1	G3WZH5	FGFR1
2		iEKPD-Sah-0100	ENSSHAG00000006217.1	G3VVF1	FGFR2
3		iEKPD-Sah-0184	ENSSHAG00000009751.1	G3W7D2	FGFR3
4		iEKPD-Sah-0240	ENSSHAG00000011893.1	G3WEQ2	FGFR4