※ FGFR family introduction

    FGFR (Fibroblast growth factor receptor) are receptor tyrosine protein kinase and involved in FGF signaling. FGFRs contain an extracellular domain which can directly bind to FGF ligand, a transmembrane and intracellular kinase domain. The combining of extracellular domain and ligand will lead to the phosphorylation of several tyrosine residues within their intracellular domains and this will increase the kinase activity of FGFRs. Activated FGFRs can interact with downstream molecules, such as PLC-1 and Crk and activate related signaling cascades pathway, which regulate distinct biological process including proliferation, differentiation, cell survival, protein synthesis, angiogenesis, cell growth and cell migration (1).

Reference
1. Acevedo, V.D., Ittmann, M. and Spencer, D.M. (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle, 8, 580-588. PMID: 19182515

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tar-0126	ENSTRUG00000004233.1	H2SCA1
2		iEKPD-Tar-0576	ENSTRUG00000017610.1	H2V7F4	fgfr2
3		iEKPD-Tar-0101	ENSTRUG00000003670.1	H2S861	LOC101063860
4		iEKPD-Tar-0604	ENSTRUG00000018627.1	H2VER7	LOC101073964
5		iEKPD-Tar-0535	ENSTRUG00000016527.1	H2UZ64	LOC101078564