※ PDGFR family introduction

    PDGFR (Platelet-derived growth factor receptor) are receptor tyrosine kinase. Two different gene encoding PDGFR-A and PDGFR-B have been identified in human genome, both of which can interact with PDGFs to regulate diverse cellular processes. PDGFRs contain similar structure, including five extracellular immunoglobulin loops and an intracellular kinase domain. PDGFRs are original inactive in unstimulated cell environment. Ligand binding leads to the dimerization of PDGFR which will mediate the autophosphorylation on tyrosine residues in intracellular domain. Activate PDGFR subsequently target the downstream signaling molecules via the docking sites and further lead to the protein-protein interactions. Via targeting to distinct molecules, PDGFRs are involved in diverse signaling pathway, including JNK/SAPK and RAS/MAPK, and some secondary effectors such as Akt, JNK, PKC and p70S6K (1).

Reference
1. Andrae, J., Gallini, R. and Betsholtz, C. (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev, 22, 1276-1312. PMID: 18483217

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Otg-0102	ENSOGAG00000004598.2	H0WQ88	CSF1R
2		iEKPD-Otg-0393	ENSOGAG00000016694.2	H0XFX5	FLT3
3		iEKPD-Otg-0220	ENSOGAG00000009550.2	H0X0T0	KIT
4		iEKPD-Otg-0298	ENSOGAG00000012544.2	H0X762	PDGFRA
5		iEKPD-Otg-0103	ENSOGAG00000004602.2	H0WQ92	PDGFRB