※ PDGFR family introduction

    PDGFR (Platelet-derived growth factor receptor) are receptor tyrosine kinase. Two different gene encoding PDGFR-A and PDGFR-B have been identified in human genome, both of which can interact with PDGFs to regulate diverse cellular processes. PDGFRs contain similar structure, including five extracellular immunoglobulin loops and an intracellular kinase domain. PDGFRs are original inactive in unstimulated cell environment. Ligand binding leads to the dimerization of PDGFR which will mediate the autophosphorylation on tyrosine residues in intracellular domain. Activate PDGFR subsequently target the downstream signaling molecules via the docking sites and further lead to the protein-protein interactions. Via targeting to distinct molecules, PDGFRs are involved in diverse signaling pathway, including JNK/SAPK and RAS/MAPK, and some secondary effectors such as Akt, JNK, PKC and p70S6K (1).

Reference
1. Andrae, J., Gallini, R. and Betsholtz, C. (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev, 22, 1276-1312. PMID: 18483217

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0249	ENSTGUG00000007756.1	H0ZBR5
2		iEKPD-Tag-0342	ENSTGUG00000011607.1	H0ZN05
3		iEKPD-Tag-0412	ENSTGUG00000014074.1	H0ZV38
4		iEKPD-Tag-0033	ENSTGUG00000000965.1	H0YRT7	CSF1R
5		iEKPD-Tag-0248	ENSTGUG00000007686.1	H0ZBL7	KIT
6		iEKPD-Tag-0031	ENSTGUG00000000942.1	H0YRS6	PDGFRB