Callithrix jacchus      TK/Src


※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Caj-1260
ENSCJAG00000004076.2
F6PHC1
BLK
2
iEKPD-Caj-1272
ENSCJAG00000009293.2
F7HSR3
FGR
3
iEKPD-Caj-1263
ENSCJAG00000004595.2
F7HTM9
FRK
4
iEKPD-Caj-1266
ENSCJAG00000004878.2
F7IB43
FYN
5
iEKPD-Caj-1295
ENSCJAG00000020750.3
F7HZQ6
HCK
6
iEKPD-Caj-1257
ENSCJAG00000000957.2
F7CSW9
LCK
7
iEKPD-Caj-1285
ENSCJAG00000016635.2
F7B7A6
LYN
8
iEKPD-Caj-1274
ENSCJAG00000010243.2
F7B1F8
PTK6
9
iEKPD-Caj-1297
ENSCJAG00000021512.2
F6W7M1
SRC
10
iEKPD-Caj-1275
ENSCJAG00000010253.2
F7H0I3
SRMS
11
iEKPD-Caj-1256
ENSCJAG00000000099.2
F7E686
YES1