※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cii-0153	ENSCING00000008549.2	F6XQJ5
2		iEKPD-Cii-0715	ENSCING00000008550.3	F6XP43
3		iEKPD-Cii-0177	ENSCING00000010134.3	F6PIA1
4		iEKPD-Cii-0208	ENSCING00000014225.2	F6Y0S7
5		iEKPD-Cii-0718	ENSCING00000016554.2	F6TXB9
6		iEKPD-Cii-0721	ENSCING00000021827.1	H2XRW6	LOC100180751
7		iEKPD-Cii-0713	ENSCING00000005770.3	F6RMF5	LOC100183015