※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ora-0452	ENSOANG00000029697.1	K7EEZ7
2		iEKPD-Ora-1162	ENSOANG00000010074.2	F6UG60	FGR
3		iEKPD-Ora-1171	ENSOANG00000012162.3	F7DLX2	FYN
4		iEKPD-Ora-1143	ENSOANG00000001195.2	F6ZYN6	LCK
5		iEKPD-Ora-1145	ENSOANG00000001315.2	F7FAC4	LOC100080924
6		iEKPD-Ora-1154	ENSOANG00000005501.3	F6X6I5	LYN
7		iEKPD-Ora-1149	ENSOANG00000004910.2	F7FTR4	PTK6
8		iEKPD-Ora-1150	ENSOANG00000004911.3	F7FMT3	SRMS
9		iEKPD-Ora-1153	ENSOANG00000005265.3	F6VI70	YES1