※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

  Reviewed (0)  or Unreviewed (10) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Otg-1301	ENSOGAG00000026548.1	H0XHQ3	BLK
2		iEKPD-Otg-1296	ENSOGAG00000015559.2	H0XDI8	FGR
3		iEKPD-Otg-1286	ENSOGAG00000009140.2	H0WZZ0	FRK
4		iEKPD-Otg-1267	ENSOGAG00000003928.2	H0WNS4	FYN
5		iEKPD-Otg-1275	ENSOGAG00000005498.2	H0WS71	HCK
6		iEKPD-Otg-1278	ENSOGAG00000005705.2	H0WSN1	LCK
7		iEKPD-Otg-1263	ENSOGAG00000003078.2	H0WM37	LYN
8		iEKPD-Otg-1295	ENSOGAG00000015510.2	H0XDE5	SRC
9		iEKPD-Otg-1285	ENSOGAG00000008816.2	H0WZA0	SRMS
10		iEKPD-Otg-1266	ENSOGAG00000003375.2	H0WMN4	YES1