※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

  Reviewed (0)  or Unreviewed (11) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0054	ENSTGUG00000001418.1	H0YT50
2		iEKPD-Tag-1304	ENSTGUG00000013299.1	H0ZSU8	BLK
3		iEKPD-Tag-1278	ENSTGUG00000000957.1	H0YRS7	FGR
4		iEKPD-Tag-1301	ENSTGUG00000011957.1	H0ZNZ2	FRK
5		iEKPD-Tag-1302	ENSTGUG00000011998.1	H0ZP43	FYN
6		iEKPD-Tag-1289	ENSTGUG00000006558.1	H0Z868	HCK
7		iEKPD-Tag-0501	ENSTGUG00000016425.1	H1A1H0	LOC100227039
8		iEKPD-Tag-1300	ENSTGUG00000011056.1	H0ZLG0	LYN
9		iEKPD-Tag-1285	ENSTGUG00000004937.1	H0Z3F7	SRC
10		iEKPD-Tag-1290	ENSTGUG00000007405.1	H0ZAM6	SRMS
11		iEKPD-Tag-1298	ENSTGUG00000010159.1	H0ZIS1	YES1