※ Tec family introduction

    Tec family kinases (TFK) represent the second largest family of non-receptor protein tyrosin kinases. Five members have been identified in human genome, Etk, Itk, Rlk, Btk and Tec. The expression of TFKs is mainly in immune system, Btk, Itk and Tec are expressed in mast cells, and some members are also found outside the hematopoietic system. TFKs are intact catalytic inactive and are recruited to membrane via the binding of PH domain to PtdIns(3,4,5)P3 phosphate. In turn, they are phosphorylated bu Src family kinases and subsequently undergo the autophosphorylation which will lead to the full activation. Activate TFKs are involved in a variety of cellular processes or signaling pathway, including cell adhesion and migration, actin reorganization, Ca2+ mobilization, apoptosis, and gene expression and transformation (1).

Reference
1. Takesono, A., Finkelstein, L.D. and Schwartzberg, P.L. (2002) Beyond calcium: new signaling pathways for Tec family kinases. J Cell Sci, 115, 3039-3048. PMID: 12118060

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cas-1207	ENSTSYG00000011035.2	A0A1U7TS48	BMX
2		iEKPD-Cas-1203	ENSTSYG00000009216.2	A0A1U7T452	BTK
3		iEKPD-Cas-1190	ENSTSYG00000002118.2	A0A1U7T0M5	ITK
4		iEKPD-Cas-1225	ENSTSYG00000037185.1	A0A1U7U4B3	TEC
5		iEKPD-Cas-1208	ENSTSYG00000011407.2	A0A1U7U634	TXK