※ Tec family introduction

    Tec family kinases (TFK) represent the second largest family of non-receptor protein tyrosin kinases. Five members have been identified in human genome, Etk, Itk, Rlk, Btk and Tec. The expression of TFKs is mainly in immune system, Btk, Itk and Tec are expressed in mast cells, and some members are also found outside the hematopoietic system. TFKs are intact catalytic inactive and are recruited to membrane via the binding of PH domain to PtdIns(3,4,5)P3 phosphate. In turn, they are phosphorylated bu Src family kinases and subsequently undergo the autophosphorylation which will lead to the full activation. Activate TFKs are involved in a variety of cellular processes or signaling pathway, including cell adhesion and migration, actin reorganization, Ca2+ mobilization, apoptosis, and gene expression and transformation (1).

Reference
1. Takesono, A., Finkelstein, L.D. and Schwartzberg, P.L. (2002) Beyond calcium: new signaling pathways for Tec family kinases. J Cell Sci, 115, 3039-3048. PMID: 12118060

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ora-1156	ENSOANG00000005862.2	F6WYI4
2		iEKPD-Ora-1166	ENSOANG00000010683.2	F6T986
3		iEKPD-Ora-1147	ENSOANG00000002579.3	F7F5Z2	BMX
4		iEKPD-Ora-1148	ENSOANG00000004224.2	F7BKT0	BTK
5		iEKPD-Ora-1151	ENSOANG00000005082.3	F6PFT9	ITK