※ Tec family introduction

    Tec family kinases (TFK) represent the second largest family of non-receptor protein tyrosin kinases. Five members have been identified in human genome, Etk, Itk, Rlk, Btk and Tec. The expression of TFKs is mainly in immune system, Btk, Itk and Tec are expressed in mast cells, and some members are also found outside the hematopoietic system. TFKs are intact catalytic inactive and are recruited to membrane via the binding of PH domain to PtdIns(3,4,5)P3 phosphate. In turn, they are phosphorylated bu Src family kinases and subsequently undergo the autophosphorylation which will lead to the full activation. Activate TFKs are involved in a variety of cellular processes or signaling pathway, including cell adhesion and migration, actin reorganization, Ca2+ mobilization, apoptosis, and gene expression and transformation (1).

Reference
1. Takesono, A., Finkelstein, L.D. and Schwartzberg, P.L. (2002) Beyond calcium: new signaling pathways for Tec family kinases. J Cell Sci, 115, 3039-3048. PMID: 12118060

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-1278	ENSSSCG00000012137.4	K7GKP6	BMX
2		iEKPD-Sus-1289	ENSSSCG00000026742.2	I3LN58	BTK
3		iEKPD-Sus-1299	ENSSSCG00000038003.1	A0A286ZPK2	ITK
4		iEKPD-Sus-1275	ENSSSCG00000008820.4	F1SEA4	TEC
5		iEKPD-Sus-1274	ENSSSCG00000008819.3	F1SEA6	TXK