※ Tec family introduction

    Tec family kinases (TFK) represent the second largest family of non-receptor protein tyrosin kinases. Five members have been identified in human genome, Etk, Itk, Rlk, Btk and Tec. The expression of TFKs is mainly in immune system, Btk, Itk and Tec are expressed in mast cells, and some members are also found outside the hematopoietic system. TFKs are intact catalytic inactive and are recruited to membrane via the binding of PH domain to PtdIns(3,4,5)P3 phosphate. In turn, they are phosphorylated bu Src family kinases and subsequently undergo the autophosphorylation which will lead to the full activation. Activate TFKs are involved in a variety of cellular processes or signaling pathway, including cell adhesion and migration, actin reorganization, Ca2+ mobilization, apoptosis, and gene expression and transformation (1).

Reference
1. Takesono, A., Finkelstein, L.D. and Schwartzberg, P.L. (2002) Beyond calcium: new signaling pathways for Tec family kinases. J Cell Sci, 115, 3039-3048. PMID: 12118060

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-1306	ENSTGUG00000015142.1	H0ZY02
2		iEKPD-Tag-1277	ENSTGUG00000000655.1	H0YQX2	ITK
3		iEKPD-Tag-1305	ENSTGUG00000013782.1	H0ZUA2	LOC100230194
4		iEKPD-Tag-1307	ENSTGUG00000015619.1	H0ZZB8	LOC105760431
5		iEKPD-Tag-1294	ENSTGUG00000008092.1	H0ZCS7	TEC