Astyanax mexicanus      TK/Trk


※ Trk family introduction

    Trk family belongs to receptor tyrosine kinase. Three members have been identified in human genome, TrkA, TrkB and TrkC. Structure analysis show that Trks share a common organization. The extracellular region contains two cystein clusters which is separated by a leucine-rich motifs (LRM), and two immunoglobulin-like domains. The intracellular region contains a TK domain. Trks play an important role in a variety of cellular processes, including neuronal survival, differentiation and plasticity. For instance, knockout of Trk will lead to the reduced axon outgrowth and increased cell death, mammalian Trks regulate the convert of short-term plasticity to long-term plasticity (1).

Reference
1. Sossin, W.S. (2006) Tracing the evolution and function of the Trk superfamily of receptor tyrosine kinases. Brain Behav Evol, 68, 145-156. PMID: 16912468


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Asm-0201
ENSAMXG00000006667.1
W5KGX6
2
iEKPD-Asm-0342
ENSAMXG00000011319.1
W5KVL0
3
iEKPD-Asm-0374
ENSAMXG00000012174.1
W5KY53
4
iEKPD-Asm-0644
ENSAMXG00000021538.1
W5LQ87
5
iEKPD-Asm-0659
ENSAMXG00000024617.1
W5LR48