※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Anc-0087	ENSACAG00000003809.3	H9G844
2		iEKPD-Anc-0176	ENSACAG00000007838.2	H9GD59	ILK
3		iEKPD-Anc-0316	ENSACAG00000013081.3	H9GJL5	MAP3K10
4		iEKPD-Anc-0025	ENSACAG00000000899.3	G1K8Z9	MAP3K12
5		iEKPD-Anc-0174	ENSACAG00000007817.3	G1KH56	MAP3K13
6		iEKPD-Anc-0137	ENSACAG00000006292.3	H9GB76	MAP3K20
7		iEKPD-Anc-0030	ENSACAG00000000975.3	G1K916	MAP3K21
8		iEKPD-Anc-0199	ENSACAG00000008524.3	G1KYM9	MAP3K7
9		iEKPD-Anc-0108	ENSACAG00000004901.3	G1KDB6	MAP3K9
10		iEKPD-Anc-0274	ENSACAG00000011525.3	H9GHZ1	tnni3k