※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

  Reviewed (17)  or Unreviewed (44) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Art-0150	AT1G51890	C0LGG6	At1g51890
2		iEKPD-Art-0346	AT2G24230	C0LGK9	At2g24230
3		iEKPD-Art-0844	AT5G10020	Q0WR59	At5g10020
4		iEKPD-Art-0937	AT5G41680	Q3E8J4	At5g41680
5		iEKPD-Art-0203	AT1G63500	F4I3M3	BSK7
6		iEKPD-Art-0936	AT5G41260	Q9FHD7	BSK8
7		iEKPD-Art-0827	AT5G03730	Q05609	CTR1
8		iEKPD-Art-0027	AT1G08720	Q9FPR3	EDR1
9		iEKPD-Art-0200	AT1G62400	Q2MHE4	HT1
10		iEKPD-Art-0430	AT2G43850	F4IS56	ILK1
11		iEKPD-Art-0343	AT2G23770	O64825	LYK4
12		iEKPD-Art-0262	AT1G73660	Q9C9U5	SIS8
13		iEKPD-Art-0347	AT2G24360	Q9ZQ31	STY13
14		iEKPD-Art-0796	AT4G35780	Q8RWL6	STY17
15		iEKPD-Art-0804	AT4G38470	F4JTP5	STY46
16		iEKPD-Art-0318	AT2G17700	O22558	STY8
17		iEKPD-Art-0057	AT1G16110	Q8GXQ3	WAKL6
18		iEKPD-Art-0002	AT1G01450	F4HSB4	At1g01450
19		iEKPD-Art-0012	AT1G04700	F4I5S1	At1g04700
20		iEKPD-Art-0063	AT1G16270	Q9SA26	At1g16270
21		iEKPD-Art-0073	AT1G18160	F4IAN2	At1g18160
22		iEKPD-Art-0206	AT1G64300	Q944S4	At1g64300
23		iEKPD-Art-0282	AT1G79570	Q9SAJ2	At1g79570
24		iEKPD-Art-0377	AT2G31010	F4IPV6	At2g31010
25		iEKPD-Art-0379	AT2G31800	Q1JPN7	At2g31800
26		iEKPD-Art-0389	AT2G35050	O64768	At2g35050
27		iEKPD-Art-0423	AT2G42640	F4IP61	At2g42640
28		iEKPD-Art-0445	AT3G01490	Q9SSA4	At3g01490
29		iEKPD-Art-0462	AT3G06620	Q9C902	At3g06620
30		iEKPD-Art-0463	AT3G06630	A0A1I9LPU6	At3g06630
31		iEKPD-Art-0464	AT3G06640	F4JC18	At3g06640
32		iEKPD-Art-0517	AT3G22750	Q9LUI6	At3g22750
33		iEKPD-Art-0527	AT3G24715	Q9LRY7	At3g24715
34		iEKPD-Art-0569	AT3G46920	A0A1I9LN82	At3g46920
35		iEKPD-Art-0570	AT3G46930	A0A1I9LS70	At3g46930
36		iEKPD-Art-0586	AT3G50730	F4J1Z7	At3g50730
37		iEKPD-Art-0621	AT3G57770	F4J3H7	At3g57770
38		iEKPD-Art-0623	AT3G58640	Q94AB2	At3g58640
39		iEKPD-Art-0625	AT3G58760	A0A1I9LMD5	At3g58760
40		iEKPD-Art-0635	AT3G59830	F4J9G8	At3g59830
41		iEKPD-Art-0704	AT4G18950	Q93Z30	At4g18950
42		iEKPD-Art-0721	AT4G23050	O82754	At4g23050
43		iEKPD-Art-0745	AT4G24480	F4JQX7	At4g24480
44		iEKPD-Art-0775	AT4G31170	Q9M085	At4g31170
45		iEKPD-Art-0780	AT4G32250	Q8RWX4	At4g32250
46		iEKPD-Art-0817	AT5G01850	A0A1P8BGL4	At5g01850
47		iEKPD-Art-0836	AT5G07140	F4K6K4	At5g07140
48		iEKPD-Art-0853	AT5G11850	Q8S9K4	At5g11850
49		iEKPD-Art-0968	AT5G50180	Q9FGS7	At5g50180
50		iEKPD-Art-1003	AT5G58950	Q9FIL6	At5g58950
51		iEKPD-Art-0639	AT3G63260	O22100	ATMRK1
52		iEKPD-Art-0535	AT3G27560	Q9LT56	ATN1
53		iEKPD-Art-0697	AT4G14780	O23334	dl3430w
54		iEKPD-Art-0933	AT5G40540	Q9FM43	MNF13.60
55		iEKPD-Art-0967	AT5G50000	Q9FGB1	MPF21.1
56		iEKPD-Art-1000	AT5G58520	Q0WN89	MQJ2.14
57		iEKPD-Art-0992	AT5G57610	Q9FKL3	MUA2.19
58		iEKPD-Art-0938	AT5G41730	Q9FGG5	MUF8.1
59		iEKPD-Art-0962	AT5G49470	F4K645	RAF10
60		iEKPD-Art-0585	AT3G50720	Q9SCQ4	T3A5.100
61		iEKPD-Art-0052	AT1G14000	Q9XI87	VH1-interacting kinase