Choloepus hoffmanni      TKL/MLK


※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126


There are 8 genes.  Reviewed (0 or Unreviewed (8

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Chh-0047
ENSCHOG00000001962.1
2
iEKPD-Chh-0112
ENSCHOG00000005087.1
3
iEKPD-Chh-0118
ENSCHOG00000005332.1
4
iEKPD-Chh-0130
ENSCHOG00000005845.1
5
iEKPD-Chh-0134
ENSCHOG00000006041.1
6
iEKPD-Chh-0234
ENSCHOG00000010453.1
7
iEKPD-Chh-0254
ENSCHOG00000011070.1
8
iEKPD-Chh-0275
ENSCHOG00000012216.1