※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cii-0081	ENSCING00000004724.3	F6QML6
2		iEKPD-Cii-0100	ENSCING00000005742.3	F6PZN7
3		iEKPD-Cii-0184	ENSCING00000011582.2	F6SNR0
4		iEKPD-Cii-0192	ENSCING00000012709.2	F6TER2
5		iEKPD-Cii-0228	ENSCING00000018819.1	H2XN38
6		iEKPD-Cii-0253	ENSCING00000022043.1	H2XVX7
7		iEKPD-Cii-0012	ENSCING00000000863.3	F6QVZ9	LOC100176290
8		iEKPD-Cii-0023	ENSCING00000001615.3	F6RZA6	LOC100184368