※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Gog-0396	ENSGGOG00000016503.3	G3RK54
2		iEKPD-Gog-0015	ENSGGOG00000000391.3	A0A2I2YX93	ILK
3		iEKPD-Gog-0034	ENSGGOG00000001392.3	G3QGC1	MAP3K10
4		iEKPD-Gog-0272	ENSGGOG00000011775.3	G3R7Y7	MAP3K11
5		iEKPD-Gog-0296	ENSGGOG00000012622.3	G3S5Z3	MAP3K12
6		iEKPD-Gog-0305	ENSGGOG00000012960.3	G3RB11	MAP3K13
7		iEKPD-Gog-0126	ENSGGOG00000005714.3	G3QSG6	MAP3K20
8		iEKPD-Gog-0125	ENSGGOG00000005704.3	G3SHL1	MAP3K21
9		iEKPD-Gog-0432	ENSGGOG00000024243.2	G3RXU7	MAP3K7
10		iEKPD-Gog-0227	ENSGGOG00000010418.3	G3R4G9	MAP3K9