※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ict-0107	ENSSTOG00000004863.3	I3M501
2		iEKPD-Ict-0173	ENSSTOG00000008323.3	I3MBG7
3		iEKPD-Ict-0247	ENSSTOG00000011619.3	I3MHP1	ILK
4		iEKPD-Ict-0389	ENSSTOG00000023587.2	I3N0G2	MAP3K12
5		iEKPD-Ict-0046	ENSSTOG00000001986.3	I3LZJ8	MAP3K13
6		iEKPD-Ict-0376	ENSSTOG00000022529.2	I3MCR4	Map3k20
7		iEKPD-Ict-0439	ENSSTOG00000027529.2	I3N8H8	MAP3K21
8		iEKPD-Ict-0219	ENSSTOG00000009986.3	A0A287DFR1	MAP3K7
9		iEKPD-Ict-0298	ENSSTOG00000014094.3	I3MM95	MAP3K9