Loxodonta africana      TKL/MLK


※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Loa-0294
ENSLAFG00000014337.3
G3TD22
ILK
2
iEKPD-Loa-0234
ENSLAFG00000011342.3
G3T7B6
LOC100674156
3
iEKPD-Loa-0042
ENSLAFG00000002204.3
G3SQ10
MAP3K10
4
iEKPD-Loa-0013
ENSLAFG00000000758.4
G3U1E9
MAP3K11
5
iEKPD-Loa-0053
ENSLAFG00000002616.3
G3SQU1
MAP3K12
6
iEKPD-Loa-0050
ENSLAFG00000002531.4
G3UHK2
MAP3K13
7
iEKPD-Loa-0352
ENSLAFG00000017140.4
G3TIB2
MAP3K20
8
iEKPD-Loa-0034
ENSLAFG00000001764.3
G3SP71
MAP3K21
9
iEKPD-Loa-0388
ENSLAFG00000018639.3
G3TL77
MAP3K7
10
iEKPD-Loa-0385
ENSLAFG00000018561.3
G3TL22
MAP3K9