※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Lua-0051	TanjilG_05517	A0A1J7IR23	TanjilG_05517
2		iEKPD-Lua-0120	TanjilG_08534	A0A1J7GXD4	TanjilG_08534
3		iEKPD-Lua-0163	TanjilG_11268	A0A1J7HRT0	TanjilG_11268
4		iEKPD-Lua-0173	TanjilG_11390	A0A1J7IIP9	TanjilG_11390
5		iEKPD-Lua-0180	TanjilG_11524	A0A1J7H1P0	TanjilG_11524
6		iEKPD-Lua-0207	TanjilG_12130	A0A1J7H870	TanjilG_12130
7		iEKPD-Lua-0211	TanjilG_12203	A0A1J7HGB7	TanjilG_12203
8		iEKPD-Lua-0230	TanjilG_12991	A0A1J7H309	TanjilG_12991
9		iEKPD-Lua-0237	TanjilG_13143	A0A1J7GJL3	TanjilG_13143
10		iEKPD-Lua-0250	TanjilG_13807	A0A1J7G1K3	TanjilG_13807
11		iEKPD-Lua-0259	TanjilG_14205	A0A1J7GKU3	TanjilG_14205
12		iEKPD-Lua-0265	TanjilG_14359	A0A1J7GQ36	TanjilG_14359
13		iEKPD-Lua-0268	TanjilG_14394	A0A1J7FV30	TanjilG_14394
14		iEKPD-Lua-0272	TanjilG_14540	A0A1J7H4R3	TanjilG_14540
15		iEKPD-Lua-0275	TanjilG_14674	A0A1J7HM64	TanjilG_14674
16		iEKPD-Lua-0332	TanjilG_17954	A0A1J7FWX7	TanjilG_17954
17		iEKPD-Lua-0336	TanjilG_18009	A0A1J7GX04	TanjilG_18009
18		iEKPD-Lua-0337	TanjilG_18019	A0A1J7GSS0	TanjilG_18019
19		iEKPD-Lua-0354	TanjilG_18772	A0A1J7H813	TanjilG_18772
20		iEKPD-Lua-0358	TanjilG_19275	A0A1J7HLW8	TanjilG_19275
21		iEKPD-Lua-0373	TanjilG_19773	A0A1J7GL21	TanjilG_19773
22		iEKPD-Lua-0391	TanjilG_20474	A0A1J7IB19	TanjilG_20474
23		iEKPD-Lua-0409	TanjilG_21695	A0A1J7G1P3	TanjilG_21695
24		iEKPD-Lua-0417	TanjilG_21959	A0A1J7HUL9	TanjilG_21959
25		iEKPD-Lua-0431	TanjilG_22915	A0A1J7HEN3	TanjilG_22915
26		iEKPD-Lua-0432	TanjilG_22965	A0A1J7HE96	TanjilG_22965
27		iEKPD-Lua-0438	TanjilG_23038	A0A1J7GDW0	TanjilG_23038
28		iEKPD-Lua-0439	TanjilG_23039	A0A1J7H8C8	TanjilG_23039
29		iEKPD-Lua-0447	TanjilG_23310	A0A1J7HWU7	TanjilG_23310
30		iEKPD-Lua-0452	TanjilG_23882	A0A1J7I9U0	TanjilG_23882
31		iEKPD-Lua-0475	TanjilG_24282	A0A1J7GJ95	TanjilG_24282
32		iEKPD-Lua-0522	TanjilG_27639	A0A1J7HUT1	TanjilG_27639
33		iEKPD-Lua-0524	TanjilG_28263	A0A1J7HQR1	TanjilG_28263
34		iEKPD-Lua-0547	TanjilG_29412	A0A1J7GXJ1	TanjilG_29412
35		iEKPD-Lua-0556	TanjilG_30524	A0A1J7HDV6	TanjilG_30524
36		iEKPD-Lua-0568	TanjilG_31405	A0A1J7FZ91	TanjilG_31405
37		iEKPD-Lua-0576	TanjilG_32163	A0A1J7IUS6	TanjilG_32163