※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-0006	MANES_01G018400	A0A2C9WH00	MANES_01G018400
2		iEKPD-Mae-0010	MANES_01G033000	A0A2C9WIU4	MANES_01G033000
3		iEKPD-Mae-0014	MANES_01G048000	A0A2C9WK75	MANES_01G048000
4		iEKPD-Mae-0047	MANES_01G125400	A0A2C9WK29	MANES_01G125400
5		iEKPD-Mae-0054	MANES_01G132400	A0A2C9WN22	MANES_01G132400
6		iEKPD-Mae-0060	MANES_01G151700	A0A2C9WNL6	MANES_01G151700
7		iEKPD-Mae-0092	MANES_01G248800	A0A2C9WNU9	MANES_01G248800
8		iEKPD-Mae-0098	MANES_01G258200	A0A2C9WP27	MANES_01G258200
9		iEKPD-Mae-0106	MANES_02G022100	A0A2C9WA78	MANES_02G022100
10		iEKPD-Mae-0122	MANES_02G072900	A0A2C9WBP5	MANES_02G072900
11		iEKPD-Mae-0126	MANES_02G082900	A0A2C9WDK1	MANES_02G082900
12		iEKPD-Mae-0127	MANES_02G083100	A0A2C9WC13	MANES_02G083100
13		iEKPD-Mae-0130	MANES_02G086000	A0A2C9WC35	MANES_02G086000
14		iEKPD-Mae-0133	MANES_02G090800	A0A2C9WDR9	MANES_02G090800
15		iEKPD-Mae-0139	MANES_02G111000	A0A2C9WFH7	MANES_02G111000
16		iEKPD-Mae-0143	MANES_02G124200	A0A2C9WD80	MANES_02G124200
17		iEKPD-Mae-0201	MANES_02G213600	A0A2C9WG11	MANES_02G213600
18		iEKPD-Mae-0271	MANES_03G126400	A0A2C9W6Y4	MANES_03G126400
19		iEKPD-Mae-0279	MANES_03G150500	A0A2C9W961	MANES_03G150500
20		iEKPD-Mae-0288	MANES_03G175000	A0A2C9W8F9	MANES_03G175000
21		iEKPD-Mae-0301	MANES_03G205200	A0A251LCX6	MANES_03G205200
22		iEKPD-Mae-0334	MANES_04G069600	A0A2C9W2S3	MANES_04G069600
23		iEKPD-Mae-0336	MANES_04G075100	A0A2C9W0G3	MANES_04G075100
24		iEKPD-Mae-0392	MANES_04G153000	A0A2C9W2S5	MANES_04G153000
25		iEKPD-Mae-0419	MANES_05G078400	A0A2C9VWH4	MANES_05G078400
26		iEKPD-Mae-0428	MANES_05G105800	A0A2C9VWI8	MANES_05G105800
27		iEKPD-Mae-0435	MANES_05G121300	A0A2C9VVK7	MANES_05G121300
28		iEKPD-Mae-0445	MANES_05G135400	A0A2C9VY53	MANES_05G135400
29		iEKPD-Mae-0461	MANES_05G189700	A0A2C9VXN3	MANES_05G189700
30		iEKPD-Mae-0470	MANES_06G007900	A0A2C9VN98	MANES_06G007900
31		iEKPD-Mae-0491	MANES_06G025700	A0A2C9VM89	MANES_06G025700
32		iEKPD-Mae-0499	MANES_06G036100	A0A2C9VML5	MANES_06G036100
33		iEKPD-Mae-0505	MANES_06G053500	A0A2C9VN68	MANES_06G053500
34		iEKPD-Mae-0521	MANES_06G103700	A0A2C9VR30	MANES_06G103700
35		iEKPD-Mae-0522	MANES_06G104400	A0A2C9VPR9	MANES_06G104400
36		iEKPD-Mae-0559	MANES_06G175900	A0A2C9VTX5	MANES_06G175900
37		iEKPD-Mae-0560	MANES_06G176000	A0A2C9VRU1	MANES_06G176000
38		iEKPD-Mae-0650	MANES_08G020600	A0A2C9VCR2	MANES_08G020600
39		iEKPD-Mae-0679	MANES_08G092400	A0A251KCZ9	MANES_08G092400
40		iEKPD-Mae-0690	MANES_08G126700	A0A2C9VFU9	MANES_08G126700
41		iEKPD-Mae-0710	MANES_08G172200	A0A2C9VIC1	MANES_08G172200
42		iEKPD-Mae-0734	MANES_09G060700	A0A2C9V8D0	MANES_09G060700
43		iEKPD-Mae-0752	MANES_09G099700	A0A2C9V9F7	MANES_09G099700
44		iEKPD-Mae-0760	MANES_09G117100	A0A2C9VBG7	MANES_09G117100
45		iEKPD-Mae-0775	MANES_09G157600	A0A2C9VB77	MANES_09G157600
46		iEKPD-Mae-0786	MANES_09G183200	A0A2C9VBX7	MANES_09G183200
47		iEKPD-Mae-0819	MANES_10G055300	A0A2C9V4S2	MANES_10G055300
48		iEKPD-Mae-0899	MANES_11G040100	A0A2C9UXY5	MANES_11G040100
49		iEKPD-Mae-0900	MANES_11G040200	A0A2C9UYA9	MANES_11G040200
50		iEKPD-Mae-0966	MANES_11G117900	A0A2C9V0J4	MANES_11G117900
51		iEKPD-Mae-0967	MANES_11G118000	A0A2C9V236	MANES_11G118000
52		iEKPD-Mae-1014	MANES_12G037300	A0A2C9UT27	MANES_12G037300
53		iEKPD-Mae-1018	MANES_12G042400	A0A2C9UUK9	MANES_12G042400
54		iEKPD-Mae-1058	MANES_12G141100	A0A2C9UYF3	MANES_12G141100
55		iEKPD-Mae-1081	MANES_13G030800	A0A2C9UNG3	MANES_13G030800
56		iEKPD-Mae-1128	MANES_14G010100	A0A2C9UIT7	MANES_14G010100
57		iEKPD-Mae-1148	MANES_14G060600	A0A2C9UIX1	MANES_14G060600
58		iEKPD-Mae-1150	MANES_14G066400	A0A2C9ULB7	MANES_14G066400
59		iEKPD-Mae-1151	MANES_14G067100	A0A2C9UJG6	MANES_14G067100
60		iEKPD-Mae-1182	MANES_14G138500	A0A2C9UL51	MANES_14G138500
61		iEKPD-Mae-1191	MANES_14G170100	A0A2C9UM36	MANES_14G170100
62		iEKPD-Mae-1195	MANES_15G000200	A0A2C9UCM9	MANES_15G000200
63		iEKPD-Mae-1204	MANES_15G031400	A0A2C9UCQ7	MANES_15G031400
64		iEKPD-Mae-1241	MANES_15G115400	A0A2C9UFA2	MANES_15G115400
65		iEKPD-Mae-1253	MANES_15G151400	A0A2C9UH71	MANES_15G151400
66		iEKPD-Mae-1261	MANES_15G183000	A0A2C9UH59	MANES_15G183000
67		iEKPD-Mae-1304	MANES_16G028700	A0A2C9U8E6	MANES_16G028700
68		iEKPD-Mae-1325	MANES_16G080200	A0A2C9U9U4	MANES_16G080200
69		iEKPD-Mae-1328	MANES_16G084200	A0A2C9UA60	MANES_16G084200
70		iEKPD-Mae-1379	MANES_17G046400	A0A251IV36	MANES_17G046400
71		iEKPD-Mae-1395	MANES_17G061900	A0A2C9U556	MANES_17G061900
72		iEKPD-Mae-1412	MANES_17G122300	A0A2C9U885	MANES_17G122300
73		iEKPD-Mae-1417	MANES_18G008800	A0A2C9TZC9	MANES_18G008800
74		iEKPD-Mae-1445	MANES_18G090300	A0A2C9U243	MANES_18G090300
75		iEKPD-Mae-1477	MANES_18G144500	A0A2C9U371	MANES_18G144500
76		iEKPD-Mae-1482	MANES_S017300	A0A199UC59	MANES_S017300
77		iEKPD-Mae-1485	MANES_S025400	A0A199UBZ2	MANES_S025400