※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mim-0033	ENSMICG00000002134.3
2		iEKPD-Mim-0041	ENSMICG00000002723.3
3		iEKPD-Mim-0217	ENSMICG00000011055.3
4		iEKPD-Mim-0228	ENSMICG00000011662.3
5		iEKPD-Mim-0253	ENSMICG00000013005.3
6		iEKPD-Mim-0300	ENSMICG00000015508.3
7		iEKPD-Mim-0308	ENSMICG00000015807.3
8		iEKPD-Mim-0443	ENSMICG00000042859.1
9		iEKPD-Mim-0459	ENSMICG00000046309.1