※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

  Reviewed (10)  or Unreviewed (0) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mum-0265	ENSMUSG00000030890.16	O55222	Ilk
2		iEKPD-Mum-0353	ENSMUSG00000040390.13	Q66L42	Map3k10
3		iEKPD-Mum-0025	ENSMUSG00000004054.8	Q80XI6	Map3k11; Mlk3
4		iEKPD-Mum-0137	ENSMUSG00000023050.8	Q60700	Map3k12; Zpk
5		iEKPD-Mum-0305	ENSMUSG00000033618.6	Q1HKZ5	Map3k13
6		iEKPD-Mum-0027	ENSMUSG00000004085.14	Q9ESL4	Map3k20; Mltk; Zak
7		iEKPD-Mum-0283	ENSMUSG00000031853.5	Q8VDG6	Map3k21; Kiaa1804; Mlk4
8		iEKPD-Mum-0216	ENSMUSG00000028284.13	Q62073	Map3k7; Tak1
9		iEKPD-Mum-0370	ENSMUSG00000042724.8	Q3U1V8	Map3k9
10		iEKPD-Mum-0351	ENSMUSG00000040086.13	Q5GIG6	Tnni3k; Cark